| 1. Round | 23/08/1980 | FC Zürich | - | FC St. Gallen | 3:1 |  |
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| 6. Round | 04/10/1980 | Neuchâtel Xamax FC | - | FC St. Gallen | 3:2 | ||||
| 7. Round | 08/10/1980 | FC St. Gallen | - | CS Chênois | 2:0 | ||||
| 8. Round | 11/10/1980 | FC St. Gallen | - | Servette FC | 1:1 | ||||
| 9. Round | 18/10/1980 | FC Luzern | - | FC St. Gallen | 0:2 | ||||
| 10. Round | 25/10/1980 | FC St. Gallen | - | AC Bellinzona | 2:2 | ||||
| 15. Round | 08/03/1981 | FC St. Gallen | - | Grasshopper Club Zürich | 2:2 | ||||
| 16. Round | 15/03/1981 | FC Chiasso | - | FC St. Gallen | 1:2 | ||||
| 17. Round | 21/03/1981 | FC St. Gallen | - | FC Basel 1893 | 1:2 | ||||
| 18. Round | 04/04/1981 | FC Sion | - | FC St. Gallen | 4:1 | ||||
| 19. Round | 11/04/1981 | FC St. Gallen | - | Neuchâtel Xamax FC | 1:2 | ||||
| 13. Round | 16/04/1981 | BSC Young Boys | - | FC St. Gallen | 3:1 | ||||
| 20. Round | 24/04/1981 | Servette FC | - | FC St. Gallen | 2:1 | ||||
| 21. Round | 02/05/1981 | FC St. Gallen | - | FC Luzern | 5:4 |  |
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| 22. Round | 09/05/1981 | AC Bellinzona | - | FC St. Gallen | 2:0 | ||||
| 25. Round | 04/06/1981 | CS Chênois | - | FC St. Gallen | 2:0 | ||||
| 26. Round | 13/06/1981 | FC St. Gallen | - | BSC Young Boys | 2:2 | |
Switzerland