| 2. Round | 15/01/2022 | UANL Tigres [U18] | - | Puebla FC [U18] | 1:0 | ||||
| 3. Round | 21/01/2022 | Puebla FC [U18] | - | Club Tijuana [U18] | 1:1 | ||||
| 4. Round | 06/02/2022 | Gallos Blancos [U18] | - | Puebla FC [U18] | 3:1 | ||||
| 5. Round | 11/02/2022 | Puebla FC [U18] | - | Atlas Guadalajara [U18] | 0:0 | ||||
| 6. Round | 18/02/2022 | Puebla FC [U18] | - | CF Monterrey [U18] | 1:1 |  |
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| 7. Round | 26/02/2022 | Deportivo Guadalajara [U18] | - | Puebla FC [U18] | 3:0 | ||||
| 8. Round | 01/03/2022 | Puebla FC [U18] | - | FC Juárez [U18] | 1:1 | |
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| 10. Round | 13/03/2022 | Atlético San Luis [U18] | - | Puebla FC [U18] | 1:0 | |
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| 13. Round | 08/04/2022 | Puebla FC [U18] | - | Pumas UNAM [U18] | 2:4 | ||||
| 14. Round | 16/04/2022 | Club León [U18] | - | Puebla FC [U18] | 5:4 | ||||
| 15. Round | 19/04/2022 | CF Pachuca [U18] | - | Puebla FC [U18] | 3:0 | ||||
| 16. Round | 22/04/2022 | Puebla FC [U18] | - | Club Necaxa [U18] | 1:4 | ||||
| 17. Round | 29/04/2022 | Mazatlán FC [U18] | - | Puebla FC [U18] | 3:2 |
Mexico