| 1. Round | 06/06/2022 | Rosario Central | - | Lanús | 0:0 |  |
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| 3. Round | 15/06/2022 | Atlético Tucumán | - | Lanús | 2:1 | ||||
| 5. Round | 26/06/2022 | River Plate | - | Lanús | 2:1 | ||||
| 6. Round | 03/07/2022 | Unión de Santa Fe | - | Lanús | 3:0 | ||||
| 16. Round | 26/08/2022 | Central Córdoba SdE | - | Lanús | 2:2 | ||||
| 17. Round | 03/09/2022 | Lanús | - | Tigre | 1:2 | ||||
| 18. Round | 09/09/2022 | Barracas Central | - | Lanús | 2:0 | ||||
| 22. Round | 02/10/2022 | Talleres de Córdoba | - | Lanús | 0:1 | |
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