| 1. Round | 07/08/2021 | SC Brühl | - | FC Zürich II | 2:5 | ||||
| 2. Round | 18/08/2021 | FC Zürich II | - | SC YF/Juventus Zürich | 1:2 |  |
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| 3. Round | 21/08/2021 | SC Cham | - | FC Zürich II | 3:0 | ||||
| 4. Round | 28/08/2021 | FC Zürich II | - | FC Black Stars Basel | 0:2 | ||||
| 5. Round | 04/09/2021 | FC Bavois | - | FC Zürich II | 2:3 | ||||
| 6. Round | 11/09/2021 | FC Zürich II | - | FC Stade Nyonnais | 0:0 | ||||
| 8. Round | 25/09/2021 | FC Zürich II | - | BSC Young Boys II | 2:2 | ||||
| 15. Round | 13/11/2021 | FC Zürich II | - | FC Breitenrain Bern | 0:0 | |
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| 16. Round | 20/11/2021 | FC Zürich II | - | SC Brühl | 0:0 | ||||
| 17. Round | 27/11/2021 | SC YF/Juventus Zürich | - | FC Zürich II | 1:2 | ||||
| 19. Round | 19/02/2022 | FC Black Stars Basel | - | FC Zürich II | 0:3 | ||||
| 20. Round | 09/03/2022 | FC Zürich II | - | FC Bavois | 2:3 | ||||
| 24. Round | 26/03/2022 | FC Zürich II | - | FC Chiasso | 1:1 | |
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| 29. Round | 23/04/2022 | FC Zürich II | - | FC Rapperswil-Jona | 2:1 | ||||
| 30. Round | 30/04/2022 | FC Breitenrain Bern | - | FC Zürich II | 3:1 |
Switzerland