| 6. Round | 15/04/2022 | Libertad de Loja | - | Atlético Santo Domingo | 1:1 | ||||
| 7. Round | 20/04/2022 | Atlético Santo Domingo | - | El Nacional | 1:1 |  |
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| 9. Round | 05/05/2022 | Atlético Santo Domingo | - | Olmedo | 1:2 |  |
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| 12. Round | 26/05/2022 | Manta | - | Atlético Santo Domingo | 2:1 | ||||
| 14. Round | 08/06/2022 | Atlético Santo Domingo | - | Libertad de Loja | 0:0 |
Ecuador