| 4. Round | 31/07/2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 8. Round | 28/08/2021 | FC Bălţi | - | FC Sheriff | 0:2 |  |
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| 9. Round | 12/09/2021 | FC Sheriff | - | CS Petrocub | 2:0 | |
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| 10. Round | 19/09/2021 | FC Zimbru | - | FC Sheriff | 1:1 | ||||
| 11. Round | 22/09/2021 | FC Sheriff | - | FC Floreşti | 4:0 | ||||
| 13. Round | 02/10/2021 | FC Milsami | - | FC Sheriff | 0:1 | ||||
| 14. Round | 16/10/2021 | FC Sheriff | - | FC Sfîntul Gheorghe | 4:0 | ||||
| 16. Round | 31/10/2021 | CS Petrocub | - | FC Sheriff | 0:2 | ||||
| 17. Round | 06/11/2021 | FC Sheriff | - | FC Zimbru | 6:0 | ||||
| 18. Round | 20/11/2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 2. Round | 02/12/2021 | CS Petrocub | - | FC Sheriff | 0:0 |
Brazil
