| 1. Round | 22/08/2021 | Blauw Geel '38 | - | OSS '20 | 0:2 | ||||
| 2. Round | 29/08/2021 | OSS '20 | - | ADO '20 | 5:1 | ||||
| 3. Round | 05/09/2021 | USV Hercules | - | OSS '20 | 3:1 | ||||
| 4. Round | 12/09/2021 | OSS '20 | - | Quick Den Haag | 1:0 | ||||
| 5. Round | 19/09/2021 | Unitas Gorinchem | - | OSS '20 | 4:2 |  |
|||
| 6. Round | 26/09/2021 | OSS '20 | - | RKSV Groene Ster | 2:0 | ||||
| 7. Round | 03/10/2021 | OSS '20 | - | EVV | 1:0 | ||||
| 8. Round | 10/10/2021 | JOS Watergraafsmeer | - | OSS '20 | 3:3 | ||||
| 9. Round | 17/10/2021 | OSS '20 | - | HVV Hollandia | 3:1 | ||||
| 10. Round | 31/10/2021 | VV UNA | - | OSS '20 | 3:1 | ||||
| 11. Round | 07/11/2021 | OSS '20 | - | RKVV DEM | 0:1 | ||||
| 12. Round | 14/11/2021 | VV Gemert | - | OSS '20 | 2:1 | ||||
| 13. Round | 21/11/2021 | OSS '20 | - | VV Dongen | 1:1 | ||||
| 16. Round | 16/03/2022 | OSS '20 | - | RKVV Westlandia | 2:1 | ||||
| 19. Round | 20/03/2022 | EVV | - | OSS '20 | 1:3 | ||||
| 21. Round | 23/03/2022 | HVV Hollandia | - | OSS '20 | 3:1 | ||||
| 20. Round | 27/03/2022 | OSS '20 | - | JOS Watergraafsmeer | 6:0 | ||||
| 24. Round | 10/04/2022 | RKVV Westlandia | - | OSS '20 | 1:3 | ||||
| 26. Round | 18/04/2022 | Quick Den Haag | - | OSS '20 | 0:2 | ||||
| 27. Round | 24/04/2022 | OSS '20 | - | OFC Oostzaan | 1:3 | ||||
| 29. Round | 08/05/2022 | OSS '20 | - | VV Gemert | 0:0 |
Netherlands