| 12. Round | 24/04/2022 | Sportivo Ameliano | - | Cerro Porteño | 0:1 | ||||
| 13. Round | 01/05/2022 | Cerro Porteño | - | Club Nacional | 1:0 |  |
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| 14. Round | 09/05/2022 | Guaraní | - | Cerro Porteño | 1:2 | |
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| 15. Round | 12/05/2022 | Cerro Porteño | - | Guaireña FC | 0:0 | ||||
| 16. Round | 15/05/2022 | Sol de América | - | Cerro Porteño | 2:1 | ||||
| 17. Round | 22/05/2022 | Club Olimpia | - | Cerro Porteño | 0:4 | ||||
| 20. Round | 21/06/2022 | Cerro Porteño | - | General Caballero DJLM | 3:1 | |
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| 21. Round | 26/06/2022 | Libertad | - | Cerro Porteño | 1:0 | ||||
| 22. Round | 02/07/2022 | Cerro Porteño | - | Tacuary | 1:0 |
Paraguay