| 1. Round | 16/07/2021 | Gallos Blancos [Women] | - | CF Monterrey [Women] | 1:1 | ||||
| 3. Round | 02/08/2021 | Pumas UNAM [Women] | - | CF Monterrey [Women] | 0:3 | ||||
| 5. Round | 14/08/2021 | Mazatlán FC [Women] | - | CF Monterrey [Women] | 0:3 | ||||
| 7. Round | 28/08/2021 | Atlas Guadalajara [Women] | - | CF Monterrey [Women] | 1:2 | ||||
| 8. Round | 07/09/2021 | CF Pachuca [Women] | - | CF Monterrey [Women] | 0:1 | ||||
| 9. Round | 12/09/2021 | CF Monterrey [Women] | - | Club Tijuana [Women] | 4:0 | ||||
| 11. Round | 05/10/2021 | CF Monterrey [Women] | - | Club León [Women] | 3:1 | ||||
| 13. Round | 18/10/2021 | Club Necaxa [Women] | - | CF Monterrey [Women] | 1:6 | ||||
| 14. Round | 02/11/2021 | CF Monterrey [Women] | - | CF América [Women] | 3:1 | ||||
| 15. Round | 07/11/2021 | Atlético San Luis [Women] | - | CF Monterrey [Women] | 0:3 | ||||
| 16. Round | 16/11/2021 | CF Monterrey [Women] | - | Deportivo Guadalajara [Women] | 2:1 | ||||
| 17. Round | 20/11/2021 | CF Monterrey [Women] | - | Cruz Azul [Women] | 5:0 |
Mexico