| 1. Round | 09/08/2022 | MFK Karviná [Youth B] | - | Slavia Praha [Youth B] | 0:5 | ||||
| 2. Round | 12/08/2022 | Slavia Praha [Youth B] | - | FK Příbram [Youth B] | 12:0 | ||||
| 3. Round | 16/08/2022 | FC Zlín [Youth B] | - | Slavia Praha [Youth B] | 2:3 | ||||
| 4. Round | 27/08/2022 | Slavia Praha [Youth B] | - | FC Hradec Králové [Youth B] | 5:1 | ||||
| 8. Round | 30/08/2022 | Slavia Praha [Youth B] | - | Dynamo České Budějovice [Youth B] | 7:0 |  |
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| 5. Round | 06/09/2022 | Vysočina Jihlava [Youth B] | - | Slavia Praha [Youth B] | 0:4 | ||||
| 6. Round | 10/09/2022 | Slavia Praha [Youth B] | - | FK Pardubice [Youth B] | 7:1 | ||||
| 7. Round | 17/09/2022 | Banik Ostrava [Youth B] | - | Slavia Praha [Youth B] | 2:2 | |
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| 9. Round | 01/10/2022 | Sigma Olomouc [Youth B] | - | Slavia Praha [Youth B] | 1:0 | ||||
| 10. Round | 08/10/2022 | Slavia Praha [Youth B] | - | 1. FC Slovácko [Youth B] | 2:2 | ||||
| 13. Round | 29/10/2022 | FC Zbrojovka Brno [Youth B] | - | Slavia Praha [Youth B] | 0:2 | ||||
| 14. Round | 05/11/2022 | AC Sparta Praha [Youth B] | - | Slavia Praha [Youth B] | 1:0 | ||||
| 15. Round | 12/11/2022 | Slavia Praha [Youth B] | - | FK Dukla Praha [Youth B] | 2:3 |
Czech Republic