| 1. Round | 25/01/2020 | Once Caldas | - | Santa Fe | 0:0 | ||||
| 2. Round | 30/01/2020 | Santa Fe | - | Envigado FC | 1:1 |  |
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| 3. Round | 03/02/2020 | Águilas Doradas | - | Santa Fe | 1:0 | ||||
| 4. Round | 09/02/2020 | Santa Fe | - | Atlético Junior | 3:1 | ||||
| 5. Round | 16/02/2020 | Patriotas FC | - | Santa Fe | 0:2 | ||||
| 6. Round | 22/02/2020 | Santa Fe | - | América de Cali | 2:0 | |
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| 7. Round | 04/03/2020 | Millonarios | - | Santa Fe | 0:0 | ||||
| 8. Round | 08/03/2020 | Santa Fe | - | Atlético Nacional | 2:2 | ||||
| 9. Round | 19/09/2020 | Deportivo Pereira | - | Santa Fe | 1:2 | ||||
| 10. Round | 28/09/2020 | Santa Fe | - | Millonarios | 1:1 | ||||
| 11. Round | 03/10/2020 | Cúcuta Deportivo | - | Santa Fe | 2:3 |  |
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| 12. Round | 06/10/2020 | Santa Fe | - | Alianza Petrolera | 4:1 | |
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| 13. Round | 13/10/2020 | Jaguares de Córdoba | - | Santa Fe | 1:1 | |
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| 14. Round | 15/10/2020 | Santa Fe | - | La Equidad | 1:0 | |
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| 15. Round | 20/10/2020 | Deportivo Cali | - | Santa Fe | 3:2 | |
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| 16. Round | 25/10/2020 | Santa Fe | - | Boyacá Chicó | 3:1 | ||||
| 17. Round | 01/11/2020 | Deportivo Pasto | - | Santa Fe | 1:1 | ||||
| 18. Round | 06/11/2020 | Santa Fe | - | Independiente Medellín | 3:0 | ||||
| 19. Round | 11/11/2020 | Santa Fe | - | Deportes Tolima | 1:0 | |
Colombia