| 4. Round | 14/08/2021 | Bohemians Praha 1905 | - | AC Sparta Praha | 1:1 | ||||
| 6. Round | 29/08/2021 | Bohemians Praha 1905 | - | FK Teplice | 4:2 |  |
|||
| 7. Round | 11/09/2021 | FC Fastav Zlín | - | Bohemians Praha 1905 | 1:3 | ||||
| 8. Round | 19/09/2021 | Bohemians Praha 1905 | - | Slavia Praha | 1:5 | ||||
| 9. Round | 25/09/2021 | Baník Ostrava | - | Bohemians Praha 1905 | 4:1 | ||||
| 10. Round | 02/10/2021 | Bohemians Praha 1905 | - | Sigma Olomouc | 2:0 | ||||
| 11. Round | 16/10/2021 | FK Mladá Boleslav | - | Bohemians Praha 1905 | 4:1 | ||||
| 12. Round | 23/10/2021 | 1. FC Slovácko | - | Bohemians Praha 1905 | 1:0 | ||||
| 19. Round | 18/12/2021 | Bohemians Praha 1905 | - | FK Pardubice | 1:2 | ||||
| 24. Round | 05/03/2022 | Sigma Olomouc | - | Bohemians Praha 1905 | 0:0 | ||||
| 25. Round | 12/03/2022 | Bohemians Praha 1905 | - | FK Mladá Boleslav | 2:2 | |
|||
| 26. Round | 19/03/2022 | Bohemians Praha 1905 | - | 1. FC Slovácko | 1:2 |
Czech Republic