| 3. Round | 05/08/2021 | Gallos Blancos [U18] | - | Club León [U18] | 0:1 | ||||
| 5. Round | 18/08/2021 | Deportivo Guadalajara [U18] | - | Club León [U18] | 1:1 | ||||
| 6. Round | 21/08/2021 | Club León [U18] | - | Santos Laguna [U18] | 3:1 | ||||
| 12. Round | 02/10/2021 | Club León [U18] | - | Atlético San Luis [U18] | 4:3 | ||||
| 14. Round | 20/10/2021 | Club León [U18] | - | Pumas UNAM [U18] | 2:1 | ||||
| 11. Round | 03/11/2021 | Cruz Azul [U18] | - | Club León [U18] | 2:3 |
Mexico