 |
 |
|
| 01/10/2021 | 17:45 | Puebla FC | - | CF Pachuca | 0:2 (0:2) | |
| 18:30 | FC Juárez | - | CF Monterrey | 3:0 (3:0) | ||
| 02/10/2021 | 15:00 | Santos Laguna | - | Mazatlán FC | 3:0 (1:0) | |
| 17:15 | Deportivo Guadalajara | - | Atlas Guadalajara | 3:0 (0:0) | ||
| 17:30 | Club León | - | Atlético San Luis | 4:3 (2:1) | ||
| 03/10/2021 | 15:00 | UANL Tigres | - | Club Necaxa | 1:1 (1:0) | |
| 17:00 | CF América | - | Pumas UNAM | 1:0 (0:0) | ||
| 17:30 | Deportivo Toluca | - | Gallos Blancos | 0:1 (0:0) | ||
| 20:45 | Club Tijuana | - | Cruz Azul | 3:2 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 12 | 9 | 1 | 2 | 25:13 | 12 | 28 |
| 2 |
|
Club Necaxa | 12 | 8 | 3 | 1 | 31:18 | 13 | 27 |
| 3 |
|
CF Pachuca | 12 | 7 | 3 | 2 | 29:12 | 17 | 24 |
| 4 |
|
Club León | 12 | 7 | 3 | 2 | 22:19 | 3 | 24 |
| 5 |
|
UANL Tigres | 12 | 6 | 4 | 2 | 21:8 | 13 | 22 |
| 6 |
|
Mazatlán FC | 12 | 6 | 3 | 3 | 19:17 | 2 | 21 |
| 7 |
|
Atlas Guadalajara | 12 | 5 | 3 | 4 | 19:17 | 2 | 18 |
| 8 |
|
Club Tijuana | 12 | 5 | 1 | 6 | 19:20 | -1 | 16 |
| 9 |
|
FC Juárez | 12 | 4 | 3 | 5 | 22:17 | 5 | 15 |
| 10 |
|
Santos Laguna | 12 | 4 | 3 | 5 | 17:16 | 1 | 15 |
| 11 |
|
Deportivo Toluca | 12 | 4 | 3 | 5 | 14:14 | 0 | 15 |
| 12 |
|
Deportivo Guadalajara | 12 | 3 | 5 | 4 | 21:20 | 1 | 14 |
| 13 |
|
Gallos Blancos | 12 | 3 | 5 | 4 | 9:10 | -1 | 14 |
| 14 |
|
Cruz Azul | 12 | 3 | 4 | 5 | 14:24 | -10 | 13 |
| 15 |
|
Atlético San Luis | 12 | 3 | 3 | 6 | 18:32 | -14 | 12 |
| 16 |
|
Pumas UNAM | 12 | 1 | 4 | 7 | 10:24 | -14 | 7 |
| 17 |
|
Puebla FC | 12 | 1 | 3 | 8 | 15:30 | -15 | 6 |
| 18 |
|
CF Monterrey | 12 | 0 | 4 | 8 | 8:22 | -14 | 4 |
| Playoffs |
