| 5. Round | 04/02/2021 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 1:2 | ||||
| 6. Round | 12/02/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 1:0 | ||||
| 7. Round | 18/02/2021 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 0:4 | ||||
| 8. Round | 25/02/2021 | Atlético San Luis [U20] | - | UANL Tigres [U20] | 2:1 |  |
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| 9. Round | 02/03/2021 | Atlas Guadalajara [U20] | - | Atlético San Luis [U20] | 2:0 | ||||
| 10. Round | 05/03/2021 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 11. Round | 14/03/2021 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 12. Round | 20/03/2021 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 4. Round | 26/03/2021 | Club León [U20] | - | Atlético San Luis [U20] | 4:2 | ||||
| 13. Round | 03/04/2021 | CF Monterrey [U20] | - | Atlético San Luis [U20] | 4:1 |  |
Mexico
USA