| 1. Round | 16/03/2022 | América de Quito | - | Atlético Santo Domingo | 0:0 | ||||
| 2. Round | 23/03/2022 | Atlético Santo Domingo | - | Independiente Juniors | 0:1 | ||||
| 3. Round | 27/03/2022 | Imbabura | - | Atlético Santo Domingo | 2:0 |  |
|||
| 4. Round | 31/03/2022 | Atlético Santo Domingo | - | Manta | 2:0 |  |
|||
| 5. Round | 06/04/2022 | Búhos ULVR | - | Atlético Santo Domingo | 1:0 | ||||
| 7. Round | 20/04/2022 | Atlético Santo Domingo | - | El Nacional | 1:1 | ||||
| 8. Round | 27/04/2022 | Chacaritas FC | - | Atlético Santo Domingo | 1:0 | ||||
| 9. Round | 05/05/2022 | Atlético Santo Domingo | - | Olmedo | 1:2 | ||||
| 10. Round | 13/05/2022 | Independiente Juniors | - | Atlético Santo Domingo | 1:0 | |
|||
| 12. Round | 26/05/2022 | Manta | - | Atlético Santo Domingo | 2:1 | ||||
| 13. Round | 01/06/2022 | Atlético Santo Domingo | - | Búhos ULVR | 1:1 | ||||
| 14. Round | 08/06/2022 | Atlético Santo Domingo | - | Libertad de Loja | 0:0 |
Ecuador