| 5. Round | 05/11/2020 | Macará | - | Mushuc Runa | 0:3 | ||||
| 6. Round | 11/11/2020 | Mushuc Runa | - | LDU Quito | 1:2 | ||||
| 7. Round | 14/11/2020 | Guayaquil City | - | Mushuc Runa | 3:2 | ||||
| 8. Round | 19/11/2020 | Mushuc Runa | - | Olmedo | 1:1 | ||||
| 9. Round | 23/11/2020 | Universidad Catolica | - | Mushuc Runa | 1:1 | ||||
| 14. Round | 17/12/2020 | Barcelona | - | Mushuc Runa | 3:0 | ||||
| 15. Round | 19/12/2020 | Mushuc Runa | - | Delfín SC | 2:0 |  |
Ecuador