| 1. Round | 21/08/2010 | 1899 Hoffenheim | - | Werder Bremen | 4:1 |  |
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| 2. Round | 28/08/2010 | FC St. Pauli | - | 1899 Hoffenheim | 0:1 | ||||
| 3. Round | 10/09/2010 | 1899 Hoffenheim | - | FC Schalke 04 | 2:0 | ||||
| 4. Round | 18/09/2010 | 1. FC Kaiserslautern | - | 1899 Hoffenheim | 2:2 | ||||
| 5. Round | 21/09/2010 | 1899 Hoffenheim | - | Bayern München | 1:2 | ||||
| 6. Round | 24/09/2010 | 1. FC Köln | - | 1899 Hoffenheim | 1:1 | |
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| 7. Round | 02/10/2010 | 1. FSV Mainz 05 | - | 1899 Hoffenheim | 4:2 | |
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| 8. Round | 17/10/2010 | 1899 Hoffenheim | - | Bor. Mönchengladbach | 3:2 | |
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| 9. Round | 24/10/2010 | Borussia Dortmund | - | 1899 Hoffenheim | 1:1 | |
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| 10. Round | 31/10/2010 | 1899 Hoffenheim | - | Hannover 96 | 4:0 | |
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| 11. Round | 06/11/2010 | Hamburger SV | - | 1899 Hoffenheim | 2:1 | ||||
| 12. Round | 14/11/2010 | 1899 Hoffenheim | - | SC Freiburg | 0:1 | ||||
| 13. Round | 20/11/2010 | Eintracht Frankfurt | - | 1899 Hoffenheim | 0:4 | ||||
| 14. Round | 27/11/2010 | 1899 Hoffenheim | - | Bayer Leverkusen | 2:2 | ||||
| 15. Round | 04/12/2010 | VfB Stuttgart | - | 1899 Hoffenheim | 1:1 | ||||
| 16. Round | 11/12/2010 | 1899 Hoffenheim | - | 1. FC Nürnberg | 1:1 | ||||
| 17. Round | 18/12/2010 | VfL Wolfsburg | - | 1899 Hoffenheim | 2:2 |
France
