| 7. Round | 02/10/2021 | FC Luzern II | - | FC Langenthal | 2:0 | ||||
| 8. Round | 16/10/2021 | SC Buochs | - | FC Luzern II | 0:0 | ||||
| 9. Round | 23/10/2021 | FC Luzern II | - | FC Bassecourt | 3:0 | ||||
| 10. Round | 30/10/2021 | FC Köniz | - | FC Luzern II | 2:1 |  |
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| 11. Round | 07/11/2021 | FC Luzern II | - | FC Wohlen | 1:3 | ||||
| 13. Round | 21/11/2021 | FC Luzern II | - | FC Kosova Zürich | 3:1 | |
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| 14. Round | 27/11/2021 | FC Luzern II | - | SV Höngg | 0:1 | ||||
| 12. Round | 04/12/2021 | Grasshopper Club Zürich II | - | FC Luzern II | 1:0 | ||||
| 15. Round | 06/03/2022 | FC Luzern II | - | FC Solothurn | 1:3 | ||||
| 16. Round | 13/03/2022 | SR Delémont | - | FC Luzern II | 2:1 | ||||
| 18. Round | 26/03/2022 | Zug 94 | - | FC Luzern II | 0:0 | ||||
| 21. Round | 23/04/2022 | FC Luzern II | - | SC Buochs | 3:0 |  |
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| 22. Round | 30/04/2022 | FC Bassecourt | - | FC Luzern II | 0:1 | ||||
| 23. Round | 07/05/2022 | FC Luzern II | - | FC Köniz | 4:2 | |
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| 24. Round | 14/05/2022 | FC Wohlen | - | FC Luzern II | 3:2 | |
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| 25. Round | 21/05/2022 | FC Luzern II | - | Grasshopper Club Zürich II | 4:0 | ||||
| 26. Round | 28/05/2022 | FC Kosova Zürich | - | FC Luzern II | 0:2 |
Switzerland
Spain