| 3. Round | 09/08/2021 | CF Pachuca [U20] | - | Atlas Guadalajara [U20] | 1:1 | ||||
| 6. Round | 21/08/2021 | Atlas Guadalajara [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 7. Round | 28/08/2021 | UANL Tigres [U20] | - | Atlas Guadalajara [U20] | 0:1 | ||||
| 9. Round | 17/09/2021 | Club Necaxa [U20] | - | Atlas Guadalajara [U20] | 1:2 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara [U20] | - | Club León [U20] | 2:1 | ||||
| 11. Round | 28/09/2021 | Atlas Guadalajara [U20] | - | Puebla FC [U20] | 3:3 | ||||
| 13. Round | 15/10/2021 | Mazatlán FC [U20] | - | Atlas Guadalajara [U20] | 3:1 | ||||
| 16. Round | 28/10/2021 | Atlas Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 |
Mexico