| 1. Round | 10/01/2021 | UANL Tigres | - | Club León | 2:0 | ||||
| 3. Round | 24/01/2021 | Atlas Guadalajara | - | UANL Tigres | 0:2 | ||||
| 4. Round | 29/01/2021 | UANL Tigres | - | Club Necaxa | 1:1 | ||||
| 7. Round | 22/02/2021 | UANL Tigres | - | Club Tijuana | 3:2 | ||||
| 8. Round | 26/02/2021 | Atlético San Luis | - | UANL Tigres | 2:2 | ||||
| 9. Round | 03/03/2021 | UANL Tigres | - | Deportivo Toluca | 0:1 | ||||
| 10. Round | 06/03/2021 | Puebla FC | - | UANL Tigres | 1:1 | ||||
| 13. Round | 05/04/2021 | Gallos Blancos | - | UANL Tigres | 0:1 |  |
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| 14. Round | 11/04/2021 | UANL Tigres | - | CF América | 1:3 | |
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| 5. Round | 15/04/2021 | FC Juárez | - | UANL Tigres | 2:3 | |
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| 15. Round | 18/04/2021 | Pumas UNAM | - | UANL Tigres | 0:0 | ||||
| 16. Round | 25/04/2021 | UANL Tigres | - | CF Monterrey | 2:1 | ||||
| 17. Round | 01/05/2021 | Deportivo Guadalajara | - | UANL Tigres | 0:0 |
Mexico