| 3. Round | 09/07/2022 | Santos Laguna [U16] | - | CF Monterrey [U16] | 3:1 |  |
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| 4. Round | 16/07/2022 | Atlético San Luis [U16] | - | Santos Laguna [U16] | 3:2 | ||||
| 5. Round | 23/07/2022 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 2:1 | ||||
| 7. Round | 06/08/2022 | Atlas Guadalajara [U16] | - | Santos Laguna [U16] | 1:2 | |
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| 8. Round | 13/08/2022 | Santos Laguna [U16] | - | UANL Tigres [U16] | 1:0 | ||||
| 10. Round | 27/08/2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 1:0 | |
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| 11. Round | 03/09/2022 | Santos Laguna [U16] | - | Club León [U16] | 5:1 | ||||
| 16. Round | 08/10/2022 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 4:0 | ||||
| 17. Round | 15/10/2022 | CF Monterrey [U16] | - | Santos Laguna [U16] | 1:2 | |
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| 18. Round | 22/10/2022 | Santos Laguna [U16] | - | Club Tijuana [U16] | 0:1 |
Mexico