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| 27/08/2022 | 15:00 | Cruz Azul | - | Pumas UNAM | 4:0 (2:0) | |
| 15:00 | Club León | - | Atlas Guadalajara | 4:4 (2:1) | ||
| 15:00 | Puebla FC | - | CF Pachuca | 1:0 (0:0) | ||
| 18:00 | Club Tijuana | - | Mazatlán FC | 0:1 (0:1) | ||
| 22:00 | Deportivo Guadalajara | - | Santos Laguna | 1:0 (0:0) | ||
| 22:00 | CF Monterrey | - | Atlético San Luis | 3:0 (0:0) | ||
| 22:00 | CF América | - | FC Juárez | 1:1 (1:1) | ||
| 13/09/2022 | 15:00 | Gallos Blancos | - | Club Necaxa | 1:4 (0:1) |
| » Tables | Home | Away | First round | Second round |
| 1 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 9 | 5 | 3 | 1 | 25:9 | 16 | 18 |
| 2 |
|
Cruz Azul | 9 | 4 | 3 | 2 | 20:12 | 8 | 15 |
| 3 |
|
CF América | 9 | 4 | 3 | 2 | 18:13 | 5 | 15 |
| 4 |
|
Pumas UNAM | 9 | 4 | 3 | 2 | 12:12 | 0 | 15 |
| 5 |
|
Deportivo Toluca | 8 | 3 | 2 | 3 | 22:19 | 3 | 11 |
| 6 |
|
FC Juárez | 9 | 2 | 4 | 3 | 10:13 | -3 | 10 |
| 7 |
|
CF Pachuca | 9 | 3 | 1 | 5 | 10:17 | -7 | 10 |
| 8 |
|
Puebla FC | 9 | 2 | 2 | 5 | 13:23 | -10 | 8 |
| 9 |
|
Gallos Blancos | 9 | 2 | 1 | 6 | 10:22 | -12 | 7 |
| 2 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 9 | 6 | 2 | 1 | 18:10 | 8 | 20 |
| 2 |
|
Santos Laguna | 9 | 6 | 1 | 2 | 13:8 | 5 | 19 |
| 3 |
|
Mazatlán FC | 9 | 6 | 1 | 2 | 12:9 | 3 | 19 |
| 4 |
|
CF Monterrey | 9 | 6 | 0 | 3 | 20:10 | 10 | 18 |
| 5 |
|
Atlas Guadalajara | 9 | 3 | 2 | 4 | 11:13 | -2 | 11 |
| 6 |
|
Club Tijuana | 9 | 3 | 2 | 4 | 10:12 | -2 | 11 |
| 7 |
|
Atlético San Luis | 9 | 2 | 2 | 5 | 16:20 | -4 | 8 |
| 8 |
|
UANL Tigres | 8 | 2 | 0 | 6 | 7:12 | -5 | 6 |
| 9 |
|
Club León | 9 | 0 | 2 | 7 | 9:22 | -13 | 2 |
| Playoffs | |
| Playoffs |
