| 2. Round | 24/07/2021 | FK Saturn | - | FK Kolomna | 3:0 | ||||
| 3. Round | 01/08/2021 | FK Kolomna | - | FK Khimki 2 | 0:3 |  |
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| 8. Round | 04/09/2021 | Kvant Obninsk | - | FK Kolomna | 2:0 | ||||
| 10. Round | 14/09/2021 | FK Kolomna | - | Rodina Moskva | 2:2 | ||||
| 17. Round | 19/10/2021 | FK Saransk | - | FK Kolomna | 5:1 | ||||
| 18. Round | 25/10/2021 | FK Kolomna | - | Kvant Obninsk | 0:2 | ||||
| 22. Round | 15/11/2021 | Metallurg Vidnoye | - | FK Kolomna | 1:4 |
Russia