| 7. Round | 26/09/1980 | Go Ahead Eagles | - | Sparta Rotterdam | 1:2 | ||||
| 8. Round | 05/10/1980 | Roda JC Kerkrade | - | Go Ahead Eagles | 2:2 | ||||
| 9. Round | 18/10/1980 | Go Ahead Eagles | - | FC Wageningen | 2:2 |  |
|||
| 10. Round | 25/10/1980 | NAC Breda | - | Go Ahead Eagles | 2:0 | ||||
| 11. Round | 31/10/1980 | Go Ahead Eagles | - | PSV Eindhoven | 1:2 | ||||
| 12. Round | 08/11/1980 | SBV Excelsior | - | Go Ahead Eagles | 3:0 | ||||
| 13. Round | 21/11/1980 | Go Ahead Eagles | - | FC Groningen | 2:0 | ||||
| 14. Round | 29/11/1980 | FC Den Haag | - | Go Ahead Eagles | 1:0 | ||||
| 16. Round | 12/12/1980 | PEC Zwolle | - | Go Ahead Eagles | 2:0 | ||||
| 15. Round | 16/12/1980 | Go Ahead Eagles | - | AZ '67 Alkmaar | 1:3 | ||||
| 17. Round | 19/12/1980 | Go Ahead Eagles | - | SC NEC | 3:1 | ||||
| 18. Round | 31/01/1981 | AFC Ajax | - | Go Ahead Eagles | 4:2 | ||||
| 19. Round | 06/02/1981 | Go Ahead Eagles | - | MVV | 4:2 | |
|||
| 20. Round | 13/02/1981 | Go Ahead Eagles | - | FC Twente | 3:0 |  |
|||
| 21. Round | 28/02/1981 | Feyenoord | - | Go Ahead Eagles | 2:2 |
Canada