| 3. Round | 22/01/2022 | Mazatlán FC | - | Deportivo Toluca | 1:2 |  |
|||
| 4. Round | 07/02/2022 | UANL Tigres | - | Mazatlán FC | 4:3 | ||||
| 5. Round | 12/02/2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
| 11. Round | 21/03/2022 | Mazatlán FC | - | Club León | 1:2 | ||||
| 9. Round | 26/03/2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 12. Round | 02/04/2022 | Atlético San Luis | - | Mazatlán FC | 1:0 | ||||
| 13. Round | 09/04/2022 | Mazatlán FC | - | Cruz Azul | 1:1 | ||||
| 15. Round | 20/04/2022 | Mazatlán FC | - | Santos Laguna | 1:0 | ||||
| 16. Round | 23/04/2022 | FC Juárez | - | Mazatlán FC | 0:2 | ||||
| 17. Round | 30/04/2022 | Mazatlán FC | - | Puebla FC | 2:1 |
Venezuela