| 1. Round | 02/07/2022 | Mazatlán FC | - | Puebla FC | 2:4 |  |
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| 2. Round | 09/07/2022 | Mazatlán FC | - | UANL Tigres | 0:1 | ||||
| 5. Round | 28/07/2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | |
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| 6. Round | 31/07/2022 | Club Tijuana | - | Mazatlán FC | 2:0 | ||||
| 7. Round | 06/08/2022 | Mazatlán FC | - | Deportivo Guadalajara | 2:1 | ||||
| 8. Round | 13/08/2022 | Club León | - | Mazatlán FC | 0:3 | |
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| 9. Round | 17/08/2022 | Mazatlán FC | - | Gallos Blancos | 1:1 | ||||
| 10. Round | 21/08/2022 | FC Juárez | - | Mazatlán FC | 1:1 | ||||
| 11. Round | 27/08/2022 | Mazatlán FC | - | CF América | 1:3 | ||||
| 12. Round | 04/09/2022 | CF Monterrey | - | Mazatlán FC | 0:0 | ||||
| 13. Round | 08/09/2022 | Mazatlán FC | - | Atlas Guadalajara | 1:0 | ||||
| 14. Round | 11/09/2022 | Cruz Azul | - | Mazatlán FC | 2:0 | ||||
| 15. Round | 17/09/2022 | Mazatlán FC | - | Deportivo Toluca | 1:1 | ||||
| 17. Round | 03/10/2022 | Santos Laguna | - | Mazatlán FC | 3:0 |
Venezuela