| 7. Round | 20/08/2022 | 12 de Octubre de Itauguá | - | Tacuary | 0:2 |  |
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| 8. Round | 28/08/2022 | Tacuary | - | Sol de América | 1:0 | ||||
| 9. Round | 03/09/2022 | Club Nacional | - | Tacuary | 1:0 |  |
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| 10. Round | 11/09/2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 11. Round | 14/09/2022 | Libertad | - | Tacuary | 2:0 | ||||
| 13. Round | 25/09/2022 | Cerro Porteño | - | Tacuary | 5:0 | ||||
| 15. Round | 06/10/2022 | Club Olimpia | - | Tacuary | 1:0 | ||||
| 16. Round | 12/10/2022 | Tacuary | - | General Caballero DJLM | 0:3 | ||||
| 18. Round | 21/10/2022 | Tacuary | - | 12 de Octubre de Itauguá | 5:1 | ||||
| 19. Round | 25/10/2022 | Sol de América | - | Tacuary | 2:2 | ||||
| 21. Round | 06/11/2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Round | 12/11/2022 | Tacuary | - | Libertad | 1:0 |
Argentina
Italy