| 1. Round | 14/02/2021 | Defensa y Justicia | - | Huracán | 3:2 | ||||
| 2. Round | 20/02/2021 | Lanús | - | Defensa y Justicia | 2:1 | ||||
| 3. Round | 26/02/2021 | Defensa y Justicia | - | Patronato de Paraná | 1:0 | ||||
| 4. Round | 07/03/2021 | Gimnasia de La Plata | - | Defensa y Justicia | 1:1 |  |
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| 5. Round | 13/03/2021 | Defensa y Justicia | - | Newell's Old Boys | 4:0 | |
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| 6. Round | 21/03/2021 | Sarmiento de Junín | - | Defensa y Justicia | 3:1 | ||||
| 7. Round | 28/03/2021 | Defensa y Justicia | - | Vélez Sarsfield | 1:1 | ||||
| 8. Round | 03/04/2021 | Boca Juniors | - | Defensa y Justicia | 2:1 | ||||
| 9. Round | 10/04/2021 | Defensa y Justicia | - | Talleres de Córdoba | 2:2 | ||||
| 10. Round | 18/04/2021 | Independiente | - | Defensa y Justicia | 1:0 | ||||
| 12. Round | 02/05/2021 | Defensa y Justicia | - | Unión de Santa Fe | 0:1 |
Argentina