| 2. Round | 28/10/2020 | Sportivo Luqueño | - | Defensa y Justicia | 1:2 | ||||
| 2. Round | 04/11/2020 | Defensa y Justicia | - | Sportivo Luqueño | 1:1 | ||||
| Round of 16 | 27/11/2020 | Defensa y Justicia | - | Vasco da Gama - RJ | 1:1 | ||||
| Quarter-finals | 16/12/2020 | Defensa y Justicia | - | Bahia - BA | 1:0 | ||||
| Semi-finals | 12/01/2021 | Coquimbo Unido | - | Defensa y Justicia | 0:0 |  |
|||
| Semi-finals | 16/01/2021 | Defensa y Justicia | - | Coquimbo Unido | 4:2 | ||||
| Final | 23/01/2021 | Lanús | - | Defensa y Justicia | 0:3 |
Argentina