| 1. Round | 25/09/1960 | AC Lanerossi Vicenza | - | SSC Napoli | 2:3 |  |
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| 2. Round | 02/10/1960 | SSC Napoli | - | Torino FC | 1:1 | |
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| 3. Round | 09/10/1960 | Lazio Roma | - | SSC Napoli | 1:1 | ||||
| 4. Round | 16/10/1960 | Bologna FC | - | SSC Napoli | 0:2 | ||||
| 5. Round | 23/10/1960 | SSC Napoli | - | AS Roma | 3:2 | |
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| 7. Round | 13/11/1960 | SSC Napoli | - | ACF Fiorentina | 1:0 | ||||
| 8. Round | 20/11/1960 | Sampdoria | - | SSC Napoli | 0:0 | ||||
| 9. Round | 27/11/1960 | SSC Napoli | - | AC Milan | 1:2 | ||||
| 10. Round | 04/12/1960 | Calcio Lecco 1912 | - | SSC Napoli | 1:0 | ||||
| 14. Round | 08/01/1961 | SSC Napoli | - | Calcio Catania | 0:1 | ||||
| 16. Round | 22/01/1961 | SSC Napoli | - | Inter | 0:0 | ||||
| 17. Round | 29/01/1961 | Calcio Padova | - | SSC Napoli | 2:0 | ||||
| 18. Round | 05/02/1961 | SSC Napoli | - | AC Lanerossi Vicenza | 0:0 | ||||
| 19. Round | 12/02/1961 | Torino FC | - | SSC Napoli | 1:0 | ||||
| 20. Round | 19/02/1961 | SSC Napoli | - | Lazio Roma | 2:5 | |
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| 23. Round | 12/03/1961 | SSC Napoli | - | SPAL Ferrara | 0:2 |
Brazil