| 1. Round | 25/07/2021 | Pumas UNAM [U20] | - | Atlas Guadalajara [U20] | 1:0 | ||||
| 2. Round | 31/07/2021 | Atlas Guadalajara [U20] | - | FC Juárez [U20] | 2:1 |  |
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| 3. Round | 09/08/2021 | CF Pachuca [U20] | - | Atlas Guadalajara [U20] | 1:1 | ||||
| 4. Round | 15/08/2021 | Atlas Guadalajara [U20] | - | CF América [U20] | 0:2 | ||||
| 5. Round | 18/08/2021 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 3:1 | ||||
| 6. Round | 21/08/2021 | Atlas Guadalajara [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 7. Round | 28/08/2021 | UANL Tigres [U20] | - | Atlas Guadalajara [U20] | 0:1 | ||||
| 8. Round | 11/09/2021 | Atlas Guadalajara [U20] | - | CF Monterrey [U20] | 3:1 | ||||
| 9. Round | 17/09/2021 | Club Necaxa [U20] | - | Atlas Guadalajara [U20] | 1:2 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara [U20] | - | Club León [U20] | 2:1 | ||||
| 11. Round | 28/09/2021 | Atlas Guadalajara [U20] | - | Puebla FC [U20] | 3:3 | |
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| 16. Round | 28/10/2021 | Atlas Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 | |
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| 17. Round | 04/11/2021 | Atlas Guadalajara [U20] | - | Gallos Blancos [U20] | 1:1 |
Mexico