| 4. Round | 26/09/2021 | PAOK Saloniki | - | AEK Athen | 2:0 | ||||
| 5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 |  |
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| 14. Round | 15/12/2021 | PAS Giannina | - | PAOK Saloniki | 0:4 | ||||
| 15. Round | 19/12/2021 | PAOK Saloniki | - | Asteras Tripolis | 3:2 | ||||
| 23. Round | 13/02/2022 | PAOK Saloniki | - | Atromitos | 1:0 | ||||
| 25. Round | 27/02/2022 | PAOK Saloniki | - | Ionikos Nikea | 1:1 | ||||
| 26. Round | 06/03/2022 | Lamia | - | PAOK Saloniki | 0:2 |
Greece