| 4. Round | 26/02/2022 | Platense | - | Banfield | 0:1 | ||||
| 5. Round | 06/03/2022 | Banfield | - | Defensa y Justicia | 2:3 | ||||
| 6. Round | 13/03/2022 | Unión de Santa Fe | - | Banfield | 2:1 | ||||
| 7. Round | 19/03/2022 | Lanús | - | Banfield | 0:1 |  |
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| 8. Round | 02/04/2022 | Banfield | - | Argentinos Juniors | 0:2 | ||||
| 9. Round | 10/04/2022 | Patronato de Paraná | - | Banfield | 0:1 | ||||
| 10. Round | 18/04/2022 | Banfield | - | River Plate | 1:2 | ||||
| 11. Round | 20/04/2022 | Newell's Old Boys | - | Banfield | 1:0 | ||||
| 13. Round | 30/04/2022 | Racing Club | - | Banfield | 1:1 |
Paraguay