| Group G | 22/04/2021 | Red Bull Bragantino | - | Deportes Tolima | 2:1 | ||||
| Group G | 29/04/2021 | Emelec | - | Red Bull Bragantino | 3:0 | ||||
| Group G | 06/05/2021 | Red Bull Bragantino | - | Talleres de Córdoba | 0:1 |  |
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| Group G | 11/05/2021 | Red Bull Bragantino | - | Emelec | 2:0 |  |
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| Group G | 19/05/2021 | Talleres de Córdoba | - | Red Bull Bragantino | 0:1 | ||||
| Group G | 26/05/2021 | Deportes Tolima | - | Red Bull Bragantino | 1:2 | ||||
| Round of 16 | 15/07/2021 | Independiente del Valle | - | Red Bull Bragantino | 0:2 | |
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| Round of 16 | 22/07/2021 | Red Bull Bragantino | - | Independiente del Valle | 1:1 | ||||
| Quarter-finals | 10/08/2021 | Rosario Central | - | Red Bull Bragantino | 3:4 | |
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| Quarter-finals | 17/08/2021 | Red Bull Bragantino | - | Rosario Central | 1:0 | ||||
| Semi-finals | 22/09/2021 | Red Bull Bragantino | - | Libertad | 2:0 | ||||
| Semi-finals | 29/09/2021 | Libertad | - | Red Bull Bragantino | 1:3 | ||||
| Final | 20/11/2021 | Athletico Paranaense | - | Red Bull Bragantino | 1:0 | |
Brazil