| 2. Round | 15/01/2022 | Club Necaxa | - | CF Monterrey | 0:4 | ||||
| 3. Round | 24/01/2022 | Santos Laguna | - | Club Necaxa | 1:4 | ||||
| 4. Round | 05/02/2022 | Club Necaxa | - | CF Pachuca | 1:3 |  |
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| 6. Round | 19/02/2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 7. Round | 26/02/2022 | Club Necaxa | - | Club León | 0:1 | ||||
| 9. Round | 05/03/2022 | Club Necaxa | - | Deportivo Toluca | 0:1 | ||||
| 10. Round | 12/03/2022 | Club Necaxa | - | Gallos Blancos | 1:0 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM | - | Club Necaxa | 1:3 | ||||
| 14. Round | 16/04/2022 | Club Necaxa | - | Atlético San Luis | 4:2 | ||||
| 15. Round | 20/04/2022 | Club Necaxa | - | UANL Tigres | 2:0 | ||||
| 16. Round | 23/04/2022 | Puebla FC | - | Club Necaxa | 0:1 |  |
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| 17. Round | 30/04/2022 | Club Necaxa | - | Deportivo Guadalajara | 0:1 |
Uruguay