| 1. Round | 02/07/2022 | Club Necaxa | - | Deportivo Toluca | 1:3 | ||||
| 2. Round | 10/07/2022 | Gallos Blancos | - | Club Necaxa | 1:2 | ||||
| 3. Round | 17/07/2022 | Pumas UNAM | - | Club Necaxa | 1:0 | ||||
| 4. Round | 23/07/2022 | Club Necaxa | - | FC Juárez | 1:0 |  |
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| 5. Round | 28/07/2022 | Club Necaxa | - | CF Pachuca | 2:0 | ||||
| 6. Round | 30/07/2022 | Cruz Azul | - | Club Necaxa | 1:0 | ||||
| 7. Round | 07/08/2022 | Atlético San Luis | - | Club Necaxa | 1:2 | |
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| 8. Round | 13/08/2022 | Club Necaxa | - | CF Monterrey | 1:2 | ||||
| 9. Round | 17/08/2022 | Puebla FC | - | Club Necaxa | 2:2 | |
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| 10. Round | 20/08/2022 | Club Necaxa | - | Deportivo Guadalajara | 0:4 | ||||
| 11. Round | 28/08/2022 | UANL Tigres | - | Club Necaxa | 0:0 | ||||
| 12. Round | 03/09/2022 | Club Necaxa | - | Club León | 3:2 | |
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| 13. Round | 07/09/2022 | Santos Laguna | - | Club Necaxa | 3:1 | ||||
| 14. Round | 11/09/2022 | Club Necaxa | - | CF América | 1:2 | |
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| 15. Round | 19/09/2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 16. Round | 24/09/2022 | Club Necaxa | - | Mazatlán FC | 2:2 | |
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| 17. Round | 02/10/2022 | Atlas Guadalajara | - | Club Necaxa | 1:0 |
Uruguay