| 12. Round | 15/09/2021 | Rampla Juniors | - | Atenas | 2:1 | ||||
| 13. Round | 22/09/2021 | Racing | - | Rampla Juniors | 2:0 | ||||
| 16. Round | 12/10/2021 | Rampla Juniors | - | Uruguay Montevideo | 1:1 |  |
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| 17. Round | 19/10/2021 | Albion | - | Rampla Juniors | 2:0 | ||||
| 19. Round | 01/11/2021 | Rampla Juniors | - | Rocha | 2:1 | ||||
| 20. Round | 10/11/2021 | CA Cerro | - | Rampla Juniors | 1:2 | ||||
| 21. Round | 18/11/2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | |
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| 22. Round | 25/11/2021 | Central Español | - | Rampla Juniors | 3:0 | |
Uruguay
Italy