| 3. Round | 21/04/2022 | Orlando City | - | Tampa Bay Rowdies | 2:1 | ||||
| 4. Round | 11/05/2022 | Orlando City | - | Philadelphia Union | 2:1 | ||||
| Round of 16 | 26/05/2022 | Orlando City | - | Inter Miami CF | 4:2 pso |  |
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| Quarter-finals | 30/06/2022 | Orlando City | - | Nashville SC | 6:5 pso | ||||
| Semi-finals | 28/07/2022 | Orlando City | - | New York RB | 5:1 | |
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| Final | 08/09/2022 | Orlando City | - | Sacramento Republic | 3:0 | |
Uruguay