| 1. Round | 10/02/2022 | Patronato de Paraná II | - | Argentinos Juniors II | 0:1 | ||||
| 2. Round | 15/02/2022 | Argentinos Juniors II | - | Newell's Old Boys II | 1:1 | ||||
| 3. Round | 19/02/2022 | Racing Club II | - | Argentinos Juniors II | 0:4 | ||||
| 4. Round | 26/02/2022 | Argentinos Juniors II | - | San Lorenzo II | 2:0 | ||||
| 5. Round | 03/03/2022 | Gimnasia de La Plata II | - | Argentinos Juniors II | 1:0 | ||||
| 6. Round | 12/03/2022 | Argentinos Juniors II | - | Defensa y Justicia II | 0:1 | ||||
| 7. Round | 20/03/2022 | Argentinos Juniors II | - | Vélez Sarsfield II | 3:3 | ||||
| 8. Round | 04/04/2022 | Banfield II | - | Argentinos Juniors II | 1:0 | ||||
| 9. Round | 09/04/2022 | River Plate II | - | Argentinos Juniors II | 0:0 | ||||
| 10. Round | 14/04/2022 | Argentinos Juniors II | - | Talleres de Córdoba II | 5:0 | ||||
| 11. Round | 21/04/2022 | Atlético Tucumán II | - | Argentinos Juniors II | 2:1 |  |
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| 12. Round | 25/04/2022 | Argentinos Juniors II | - | Sarmiento de Junín II | 0:0 | ||||
| 13. Round | 02/05/2022 | Platense II | - | Argentinos Juniors II | 1:1 | ||||
| 14. Round | 05/05/2022 | Argentinos Juniors II | - | Unión de Santa Fe II | 4:0 | |
Spain