| 1° División | 03/11/19 | CF América | - | Santos Laguna | 1:2 | ||||
| 1° División | 13/09/20 | UANL Tigres | - | Santos Laguna | 2:0 | ||||
| 1° División | 09/11/20 | Santos Laguna | - | Mazatlán FC | 4:0 | ||||
| 1° División | 23/01/21 | Mazatlán FC | - | Santos Laguna | 0:0 | ||||
| 1° División | 15/02/21 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 1° División | 14/03/21 | Club Tijuana | - | Santos Laguna | 0:1 |  |
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| 1° División | 17/05/21 | CF Monterrey | - | Santos Laguna | 1:1 |  |
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| 1° División | 20/09/21 | Santos Laguna | - | Puebla FC | 1:1 | ||||
| 1° División | 21/11/21 | Santos Laguna | - | Atlético San Luis | 2:0 | ||||
| 1° División | 16/01/22 | Deportivo Toluca | - | Santos Laguna | 3:1 | ||||
| 1° División | 28/02/22 | Cruz Azul | - | Santos Laguna | 1:2 | ||||
| 1° División | 17/04/22 | Santos Laguna | - | Gallos Blancos | 1:1 | ||||
| 1° División | 09/07/22 | Puebla FC | - | Santos Laguna | 1:0 | ||||
| 1° División | 01/08/22 | Santos Laguna | - | Atlas Guadalajara | 1:0 | |
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| 1° División | 21/01/23 | Mazatlán FC | - | Santos Laguna | 1:2 | ||||
| 1° División | 27/11/23 | Club León | - | Santos Laguna | 3:2 |
Ecuador