| 1° División | 08/02/20 | Puebla FC | - | Santos Laguna | 2:2 | ||||
| 1° División | 05/09/20 | FC Juárez | - | Santos Laguna | 1:1 | ||||
| 1° División | 03/10/20 | Puebla FC | - | Santos Laguna | 0:2 | ||||
| 1° División | 22/11/20 | Santos Laguna | - | CF Pachuca | 0:3 | ||||
| 1° División | 21/05/21 | Santos Laguna | - | Puebla FC | 3:0 | ||||
| 1° División | 08/08/21 | UANL Tigres | - | Santos Laguna | 1:1 |  |
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| 1° División | 27/09/21 | Santos Laguna | - | CF Monterrey | 1:2 | ||||
| 1° División | 20/10/21 | CF América | - | Santos Laguna | 2:1 | ||||
| 1° División | 10/04/22 | CF Monterrey | - | Santos Laguna | 1:0 | ||||
| 1° División | 17/07/22 | Santos Laguna | - | Deportivo Guadalajara | 1:1 | ||||
| 1° División | 21/08/22 | Pumas UNAM | - | Santos Laguna | 1:5 | ||||
| 1° División | 27/01/23 | Atlas Guadalajara | - | Santos Laguna | 2:2 | |
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| 1° División | 17/04/23 | CF Monterrey | - | Santos Laguna | 1:2 | ||||
| 1° División | 21/08/23 | Cruz Azul | - | Santos Laguna | 2:2 | ||||
| 1° División | 09/10/23 | Santos Laguna | - | Club León | 0:2 |  |
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| 1° División | 11/11/23 | Atlético San Luis | - | Santos Laguna | 0:2 |  |
Ecuador