| 4. Round | 12/08/2019 | Santos Laguna | - | Puebla FC | 4:1 | ||||
| 5. Round | 18/08/2019 | Club Necaxa | - | Santos Laguna | 3:0 | ||||
| 6. Round | 24/08/2019 | Santos Laguna | - | CF Monterrey | 2:1 | ||||
| 7. Round | 29/08/2019 | Club León | - | Santos Laguna | 2:2 | ||||
| 11. Round | 26/09/2019 | Santos Laguna | - | CD Veracruz | 5:0 | ||||
| 19. Round | 24/11/2019 | Deportivo Toluca | - | Santos Laguna | 2:2 |
Ecuador