| 5. Round | 09/02/2021 | Club León | - | Deportivo Guadalajara | 1:3 | ||||
| 6. Round | 13/02/2021 | Club Tijuana | - | Club León | 2:0 | ||||
| 7. Round | 21/02/2021 | Pumas UNAM | - | Club León | 0:1 | ||||
| 8. Round | 28/02/2021 | Club León | - | Cruz Azul | 0:1 | ||||
| 9. Round | 03/03/2021 | Club León | - | Puebla FC | 1:2 |  |
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| 10. Round | 07/03/2021 | CF América | - | Club León | 2:1 | ||||
| 3. Round | 11/03/2021 | CF Monterrey | - | Club León | 1:1 | ||||
| 11. Round | 16/03/2021 | Club León | - | Club Necaxa | 3:1 | ||||
| 12. Round | 22/03/2021 | Santos Laguna | - | Club León | 1:2 |  |
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| 13. Round | 05/04/2021 | Club León | - | Deportivo Toluca | 2:1 | ||||
| 15. Round | 20/04/2021 | Club León | - | FC Juárez | 2:0 |
Mexico