| 3. Round | 22/01/2021 | Puebla FC [U20] | - | Club Tijuana [U20] | 0:2 | ||||
| 5. Round | 06/02/2021 | CF América [U20] | - | Puebla FC [U20] | 4:1 | ||||
| 10. Round | 05/03/2021 | Puebla FC [U20] | - | UANL Tigres [U20] | 3:2 | ||||
| 11. Round | 12/03/2021 | Puebla FC [U20] | - | Atlas Guadalajara [U20] | 0:5 | ||||
| 12. Round | 21/03/2021 | Deportivo Toluca [U20] | - | Puebla FC [U20] | 1:2 | ||||
| 1. Round | 27/03/2021 | Puebla FC [U20] | - | Deportivo Guadalajara [U20] | 2:4 | ||||
| 13. Round | 02/04/2021 | Puebla FC [U20] | - | Mazatlán FC [U20] | 6:2 | ||||
| 4. Round | 07/04/2021 | Puebla FC [U20] | - | CF Monterrey [U20] | 2:3 | ||||
| 14. Round | 12/04/2021 | CF Pachuca [U20] | - | Puebla FC [U20] | 5:2 | ||||
| 17. Round | 02/05/2021 | Santos Laguna [U20] | - | Puebla FC [U20] | 2:3 |
Mexico