| 2. Round | 13/03/2021 | Atlético Palmaflor | - | Real Santa Cruz | 1:0 | ||||
| 1. Round | 20/03/2021 | Club San José | - | Atlético Palmaflor | 1:3 | ||||
| 3. Round | 28/03/2021 | Nacional Potosí | - | Atlético Palmaflor | 3:2 | ||||
| 4. Round | 10/04/2021 | Atlético Palmaflor | - | Oriente Petrolero | 2:1 | ||||
| 5. Round | 26/04/2021 | The Strongest | - | Atlético Palmaflor | 4:1 | ||||
| 6. Round | 03/05/2021 | Atlético Palmaflor | - | Jorge Wilstermann | 3:1 |  |
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| 7. Round | 09/05/2021 | Independiente Petrolero | - | Atlético Palmaflor | 2:0 | ||||
| 11. Round | 25/07/2021 | Atlético Palmaflor | - | CD Guabirá | 2:1 | ||||
| 12. Round | 31/07/2021 | Blooming | - | Atlético Palmaflor | 1:1 | |
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| 13. Round | 03/08/2021 | Atlético Palmaflor | - | Bolívar | 2:2 |  |
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| 14. Round | 08/08/2021 | Club Aurora | - | Atlético Palmaflor | 2:1 | ||||
| 16. Round | 18/08/2021 | Atlético Palmaflor | - | Club San José | 1:0 | |
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| 17. Round | 23/08/2021 | Real Santa Cruz | - | Atlético Palmaflor | 1:0 | ||||
| 22. Round | 21/10/2021 | Atlético Palmaflor | - | Independiente Petrolero | 0:0 | ||||
| 24. Round | 28/10/2021 | Royal Pari | - | Atlético Palmaflor | 2:2 | ||||
| 25. Round | 02/11/2021 | Atlético Palmaflor | - | Real Potosí | 0:1 |
Bolivia