| 3. Round | 24/01/2021 | Deportivo Toluca [U20] | - | Club Necaxa [U20] | 3:0 | ||||
| 4. Round | 30/01/2021 | Club Tijuana [U20] | - | Deportivo Toluca [U20] | 1:2 |  |
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| 5. Round | 07/02/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | |
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| 6. Round | 14/02/2021 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 2:2 | ||||
| 7. Round | 20/02/2021 | Cruz Azul [U20] | - | Deportivo Toluca [U20] | 0:3 | ||||
| 8. Round | 27/02/2021 | Deportivo Toluca [U20] | - | Atlas Guadalajara [U20] | 0:1 | ||||
| 13. Round | 04/04/2021 | Club León [U20] | - | Deportivo Toluca [U20] | 0:4 | ||||
| 14. Round | 11/04/2021 | Deportivo Toluca [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 15. Round | 18/04/2021 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:2 | ||||
| 16. Round | 25/04/2021 | Deportivo Toluca [U20] | - | CF América [U20] | 0:2 |  |
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| 17. Round | 30/04/2021 | FC Juárez [U20] | - | Deportivo Toluca [U20] | 0:0 |
USA