| 1. Round | 11/09/2020 | PAOK Saloniki | - | AE Lárissa | 1:0 | ||||
| 2. Round | 18/09/2020 | PAOK Saloniki | - | Atromitos | 1:1 | ||||
| 4. Round | 04/10/2020 | PAOK Saloniki | - | OFI Heraklion | 3:0 | ||||
| 5. Round | 18/10/2020 | AEK Athen | - | PAOK Saloniki | 1:1 | ||||
| 7. Round | 01/11/2020 | Panetolikos | - | PAOK Saloniki | 1:3 | ||||
| 9. Round | 22/11/2020 | PAOK Saloniki | - | PAS Giannina | 2:1 | ||||
| 14. Round | 03/01/2021 | AE Lárissa | - | PAOK Saloniki | 1:1 |  |
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| 17. Round | 17/01/2021 | OFI Heraklion | - | PAOK Saloniki | 0:3 |  |
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| 18. Round | 24/01/2021 | PAOK Saloniki | - | AEK Athen | 2:2 | ||||
| 19. Round | 27/01/2021 | Olympiakos Piraeus | - | PAOK Saloniki | 3:0 | ||||
| 20. Round | 31/01/2021 | PAOK Saloniki | - | Panetolikos | 5:0 | ||||
| 21. Round | 07/02/2021 | PAOK Saloniki | - | Apollon Smyrnis | 2:2 | ||||
| 22. Round | 15/02/2021 | PAS Giannina | - | PAOK Saloniki | 0:2 | ||||
| 23. Round | 21/02/2021 | PAOK Saloniki | - | Lamia | 4:0 | ||||
| 24. Round | 27/02/2021 | Asteras Tripolis | - | PAOK Saloniki | 2:1 | ||||
| 25. Round | 07/03/2021 | PAOK Saloniki | - | Aris Saloniki | 2:2 |
Portugal