Round of 16 | 16/02/2022 | Deportivo Guastatoya | - | Club León | 0:2 | ||||
Round of 16 | 23/02/2022 | Club León | - | Deportivo Guastatoya | 1:0 | ||||
Quarter-finals | 09/03/2022 | Seattle Sounders | - | Club León | 3:0 | ||||
Quarter-finals | 18/03/2022 | Club León | - | Seattle Sounders | 1:1 |