 |
 |
|
|
| 1st(1st leg) | New York City FC | - | Comunicaciones | 3:1 (1:0) | ||
| 2nd (2nd leg) | Comunicaciones | - | New York City FC | 4:2 (1:1) | ||
| 1st(1st leg): 09/03/2022 01:00 | 2nd (2nd leg): 16/03/2022 00:00 | Winner: New York City FC | ||||
| 1st(1st leg) | Seattle Sounders | - | Club León | 3:0 (2:0) | ||
| 2nd (2nd leg) | Club León | - | Seattle Sounders | 1:1 (0:1) | ||
| 1st(1st leg): 09/03/2022 03:00 | 2nd (2nd leg): 18/03/2022 00:30 | Winner: Seattle Sounders | ||||
| 1st(1st leg) | New England Revolution | - | Pumas UNAM | 3:0 (1:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | New England Revolution | 3:0 (1:0) pso | ||
| 1st(1st leg): 10/03/2022 01:00 | 2nd (2nd leg): 17/03/2022 02:15 | Winner: Pumas UNAM | ||||
| 1st(1st leg) | Cruz Azul | - | CF Montréal | 1:0 (1:0) | ||
| 2nd (2nd leg) | CF Montréal | - | Cruz Azul | 1:1 (0:1) | ||
| 1st(1st leg): 10/03/2022 03:00 | 2nd (2nd leg): 17/03/2022 00:00 | Winner: Cruz Azul | ||||
